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If metformin-associated lactic acidosis is suspectedgeneral supportive measures should be instituted promptly in a hospital settingalong with immediate discontinuation of GlucovanceIn Glucovance treated patients with a diagnosis or strong suspicion of lactic acidosisprompt hemodialysis is recommended to correct the acidosis and remove accumulated metforminmetformin hydrochloride is dialyzable with a clearance of up to 170 mL/min under good hemodynamic conditionsHemodialysis has often resulted in reversal of symptoms and recovery.

Call your doctor if you are sick with vomitingdiarrheaor a feverThese conditions can lead to severe dehydrationwhich could be dangerous while you are taking Glucovance.

Glucovance is available for oral administration in tablets containing2.5 mg glyburide with 500 mg metformin hydrochlorideand 5 mg glyburide with 500 mg metformin hydrochlorideIn additioneach tablet contains the following inactive ingredientsmicrocrystalline cellulosepovidonecroscarmellose sodiumand magnesium stearateThe tablets are film coatedwhich provides color differentiation.

Table 3Glucovance in Patients with Inadequate Glycemic Control on Sulfonylurea AloneSummary of Trial Data at 16 Weeks.

Use this medication regularly to get the most benefit from itTo help you remembertake it at the same time(seach day.

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following administration of a single glucovance mite 5 mg 500 mg tablet with either a 20 glucose solution or a 20 glucose solution with food, there was no effect of food on the c max and a relatively small effect of food on the auc of the glucovance mite component.

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